Alza corporation

The medication remained encapsulated until it reached the areas of disease within the body, thereby delivering higher concentrations of the drug to these areas while bypassing healthy tissue which resulted in reduced side effects.

Alza corporation

Another joint effort, with Pfizer Inc. In addition to providing consistent drug levels in the bloodstream, the transdermal system offered improved absorption. ALZA also continued its research into electrotransport, developing prototypes of small, reusable devices that delivered drug dosages through the skin. Another key development came late in when a new management team was installed to implement the company's new strategy. The tablet facilitated the workings of the syringe pump, so that a mixture of water and drug could be introduced into the patient's bloodstream. The fledgling company leased land in Stanford's Research Park for its first facility, and Martin Gerstel, who had recently graduated from Stanford's business school, became the company's second employee after Zaffaroni. One of ALZA's first self-developed and self-marketed products was the Testoderm system, which was introduced early in ALZA Corporation, headquartered in Mountain View, California, is a research-based pharmaceutical company with leading drug delivery technologies. The company applies its delivery technologies to develop pharmaceutical products with enhanced therapeutic value for its own portfolio and for many of the world's leading pharmaceutical companies. History of ALZA Corporation As one of the world's leading producers of drug delivery systems, ALZA Corporation develops and manufactures a variety of systems that make administration of medication more efficient and effective. The company had its first profitable year in and was listed on the American Stock Exchange. Mario became sole chairman at the end of upon Zaffaroni's retirement. The new therapy, Calan OROS, was designed to release medication early in the morning, when dangers from high blood pressure are greatest. This was the beginning of a difficult five-year period for ALZA and its stockholders, who began losing money. The transdermal system was innovative because it would allow medicines to be absorbed through the skin for a controlled, continuous dosage.

Procardia XL reflected ALZA's contribution to osmotic technology, which controlled the release rate of medication in capsule or tablet form. InALZA announced the development of two new systems based on its proprietary osmotic technology.

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When a patient swallowed an OROS tablet, water would be drawn from the membrane to saturate the drug, which would then be released in liquid form drop by drop through laser-drilled holes in the tablet. The following year, ALZA purchased land in Vacaville, California, to build a ,square-foot commercial manufacturing facility. He wanted that title. Being acquired by Abbott thereby appeared to be part of ALZA's move toward becoming a fully integrated drug firm. The fledgling company leased land in Stanford's Research Park for its first facility, and Martin Gerstel, who had recently graduated from Stanford's business school, became the company's second employee after Zaffaroni. One system, Chronset, was designed to deliver proteins and peptides orally. The mild electrical currents emitted by the system propelled controlled, consistent dosages into the bloodstream and allowed the patient direct control. Although the FDA approved Nicoderm in November, sales of the breakthrough technology were suspended by court order for one month, when an Irish pharmaceutical company, Elan Corp. The transdermal system was innovative because it would allow medicines to be absorbed through the skin for a controlled, continuous dosage. Company Perspectives: ALZA's strategy is to target a number of specialty market opportunities in order to build a strong commercial presence, advance and broaden its product pipeline and maintain its technological leadership in drug delivery. In , to consolidate its stake in electrotransport systems, the company announced that it would acquire Bio-Electro Systems as well as Medtronic Inc. An immediate consequence of the collapse of the merger was that ALZA retained a promising prostate-cancer drug, Viadur, which it would have had to divest because Abbott had its own prostate-cancer treatment, Lupron. In , ALZA announced the development of two new systems based on its proprietary osmotic technology. Doxil was the first medication delivered via the Stealth technology.

Although the company was small, it pursued its mission diligently, filing a patent application for a transdermal system invented by Zaffaroni in Additional Details. These statements are based on current expectations, forecasts and assumptions that are subject to risks and uncertainties which could cause actual outcomes and results to differ materially from these statements.

A wearable, disposable system, the pump consisted of two reservoirs--one for water and one for the drug being administered--and an osmotic tablet compartment. During the final months ofALZA and Marion Merrell Dow faced a patent lawsuit that threatened the introduction of Nicoderm, the first transdermal nicotine delivery system.

Ethyol was initially approved for patients undergoing chemotherapy to treat kidney-related side effects, then in was approved to protect the salivary glands of head and neck cancer patients undergoing radiation therapy.

This was the beginning of a difficult five-year period for ALZA and its stockholders, who began losing money. More than 50 new products were in development, including an oral form of an anti-epileptic drug, Dilantin.

Although the FDA approved Nicoderm in November, sales of the breakthrough technology were suspended by court order for one month, when an Irish pharmaceutical company, Elan Corp.

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The fledgling company leased land in Stanford's Research Park for its first facility, and Martin Gerstel, who had recently graduated from Stanford's business school, became the company's second employee after Zaffaroni.

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